Modafinil is a wakefulness-promoting drug used to improve wakefulness in patients with excessive sleepiness caused by narcolepsy, shift work sleep disorder, or obstructive sleep apnea/hypopnea syndrome (OSAHS). It has been proven effective and well tolerated in several large-scale, double blind, placebo controlled clinical trials.
In OSAHS studies, modafinil australia online is used along with standard therapy for the underlying obstructive airway obstruction. Despite treatment with CPAP, residual EDS may persist.
Narcolepsy
Narcolepsy is a condition that causes excessive daytime sleepiness. It can cause people to fall asleep at the most inappropriate times, even if they are doing something active. It can also cause them to experience frequent memory lapses and feel tired and depressed.
It can lead to dangerous driving, which is why people with narcolepsy should seek medical attention to treat their condition. Getting enough sleep at night doesn’t always help with this problem, so patients may need to use medications like Provigil. This medicine reduces sleepiness by stimulating the brain.
It works as a stimulant, copying the activity of brain chemicals that act like adrenaline and increasing the activity of dopamine. It comes in a tablet form and is taken once per day. People with narcolepsy should take it in the morning after waking up. Those with shift work sleep disorder should take it about an hour before they start their shift.
Modafinil is a prescription drug that is used to treat narcolepsy and other sleep disorders. It is also used in combination with other treatments, such as sleep apnea devices and behavioral therapy, to prevent sleepiness caused by obstructive sleep apnea/hypopnea syndrome (OSAHS).
It is available only with a doctor’s prescription and should be taken at the same time each day. It is not a cure for these conditions, but it can help improve wakefulness and reduce the risk of accidents. In a number of studies, modafinil has been shown to be effective in improving wakefulness. These trials were double-blind and placebo controlled.
Sleep apnea
Sleep apnea is a condition that causes breathing to stop and start repeatedly while sleeping. It can cause problems ranging from poor memory and concentration to severe health issues like heart disease and stroke. If you have symptoms of sleep apnea, including excessive daytime sleepiness, talk to your doctor about getting an evaluation. A sleep study may be performed at the clinic or in your home.
Modalert Tablet is in a class of medications called wakefulness-promoting agents. It can help people with narcolepsy, obstructive sleep apnea/hypopnea syndrome (OSAHS), and shift work sleep disorder stay awake during the day. It is not a cure for these conditions, but it can improve their symptoms and prevent them from interfering with daily activities.
In two placebo controlled studies, modafinil 400 mg taken either once a day or as a split dose in the morning and at midday significantly improved objectively determined wakefulness on the Multiple Sleep Latency Test (MSLT), the Maintenance of Wakefulness Test (MWT), and the Epworth Sleepiness Scale (ESS) over 12 weeks.
It also improved vigilance and overall clinical condition. However, modafinil does not treat the underlying obstruction in OSA and should be used as an adjunct to other treatments such as continuous positive airway pressure (CPAP).
Clinical studies of the R-enantiomer of modafinil, now sold as NUVIGIL® (armodafinil), suggest that it has similar wake-promoting activity to modafinil but is longer lasting than the S-enantiomer, which has a shorter half-life.
Shift work sleep disorder
Shift work sleep disorder (SWSD) occurs when a nontraditional shift schedule disrupts your body’s internal clock that regulates sleep-wake cycles. It usually affects people who work night shifts, graveyard shifts or rotating shifts. It can cause fatigue, drowsiness and inability to concentrate. It can also affect your quality of life and health.
Symptoms of SWSD include insomnia, excessive sleepiness while awake and a lack of refreshing sleep. These symptoms can occur for a month or more and are associated with the type of shift you work. If you have these symptoms, it’s important to talk to your doctor about treatment options.
Many shift workers have trouble getting enough restful sleep, and this can lead to poor performance at work. In addition, the stress of working shifts may increase your risk for heart disease and other conditions. Shift workers can suffer from low testosterone, which can cause low energy and a decreased libido.
Provigil is a medication that reduces sleepiness by stimulating the brain. It works by mimicking the action of adrenaline and increasing the activity of another brain chemical called dopamine. It is taken orally, once per day, and it can be a good option for those with narcolepsy and other sleep disorders. However, sleeping pills should not be used as a long-term solution for improving sleep problems because they can lead to dependence and have negative side effects.
Fatigue
Fatigue is a common problem and can be difficult to treat. It can be caused by many things, including sleep disorders, stress, lack of exercise, depression, and medications. Some people are prone to fatigue because of their genetics. However, getting enough sleep and having a healthy diet can help reduce fatigue. In addition, it is important to avoid alcoholic beverages and other stimulants such as caffeine.
The drug modafinil is a wake-promoting agent that has U.S. Food and Drug Administration approval for the treatment of narcolepsy and shift work sleep disorder, as well as adjunctive therapy in obstructive sleep apnea/hypopnea syndrome (OSAHS).
It is a racemic compound that has two enantiomers that differ in pharmacokinetic properties. The R-enantiomer (also known as armodafinil) has a longer half-life than the S-enantiomer, and its wake-promoting activity is likely to be due to increased availability of dopamine.
In large, double blind, placebo controlled studies of patients with narcolepsy and shift work disorder, modafinil significantly improved wakefulness as measured by objective criteria such as multiple sleep latency tests or maintenance of wakefulness tests and subjective ratings of self-rated sleepiness using the Epworth Sleepiness Scale.
The drug also has cognitive-enhancing effects and improves performance on certain basic testing tasks, such as processing speed and verbal learning. However, the effect on cognition is modest and may be a result of the improved wakefulness rather than the drug’s direct action on dopamine.
