Abbott Alinity CI Calibration & Quality Control Best Practices

Introduction

Calibration and quality control (QC) are essential for getting reliable and accurate results in any clinical laboratory. For labs using the Abbott Alinity CI Analyzer, following proper calibration and QC practices ensures smooth operation and high confidence in every test run.

In this guide, we’ll explore the best practices for calibrating and managing quality control on the Alinity CI system, helping lab professionals maintain peak performance and compliance.

Understanding Calibration and Quality Control

What is Calibration?

Calibration ensures that the analyzer gives the correct result for a known value. It aligns the instrument’s measurements with the reference standard.

What is Quality Control?

Quality control monitors the accuracy and precision of test results over time. QC samples have known values, and when run on the analyzer, the results must match expected ranges.

Together, calibration and QC are the backbone of reliable lab testing.

When to Calibrate the Abbott Alinity CI

Calibration isn’t a one-time task. Labs should calibrate:

• When a new reagent pack is loaded

• When manufacturer instructions require it

• After replacing key components (like probes or sensors)

• If QC results show deviation

• At scheduled intervals (weekly, bi-weekly, or monthly)

The Alinity CI system provides on-screen prompts and a clear calibration schedule. Following this helps labs avoid test drift and maintain compliance with CLIA, CAP, and other regulatory standards.

How to Perform Calibration on the Alinity CI

The Alinity CI makes calibration easy with step-by-step automation. Here’s a basic overview:

1. Load Calibrators

Use only approved calibrators from Abbott. Load them just like samples, using the sample rack or carousel.

2. Initiate Calibration

Through the user interface:

• Go to the Calibration menu

• Select the analyte or reagent to calibrate

• Start the calibration process

3. Review Results

Once complete, the system will:

• Accept the calibration if within expected ranges

• Flag issues if the curve fails or is inconsistent

In case of failure, it may prompt a retest or a reagent check.

Tips for Better Calibration

• Always check expiration dates of calibrators

• Run calibrators at room temperature

• Handle all liquids and containers with clean gloves

• Never skip calibration prompts from the system

Also, make sure to document all calibration activity in the lab’s quality log or digital record-keeping system.

Quality Control: Daily, Weekly & Monthly Best Practices

Daily QC Tasks

• Run 2 levels of control samples (normal and abnormal)

• Review control results for each analyte tested

• Confirm values fall within acceptable ranges

Weekly QC Tasks

• Review QC trends and patterns

• Look for shifts, trends, or random errors

• Adjust or recalibrate if needed

Monthly QC Tasks

• Perform a full QC summary review

• Compare across instruments or shifts

• Check lot-to-lot consistency in control materials

Using the Alinity CI QC Features

The Alinity CI software includes built-in QC tools:

• Levey-Jennings charts to spot trends

• Westgard rules to identify errors

• Alerts for out-of-range values

These tools support proactive troubleshooting and help lab staff maintain accuracy without guesswork.

Common Calibration & QC Issues (and How to Fix Them)

Training & Documentation

For long-term success, labs must:

• Train all team members on calibration and QC steps

• Keep detailed logs of calibration/QC activity

• Use SOPs (Standard Operating Procedures) for all checks

• Review records regularly to identify long-term trends

Regulatory Compliance

Proper calibration and QC also help meet regulatory requirements set by:

• CLIA (Clinical Laboratory Improvement Amendments)

• CAP (College of American Pathologists)

• ISO 15189 for medical lab quality

Maintaining compliance improves lab audits and boosts trust with healthcare providers.

Summary

The Abbott Alinity CI Analyzer is known for accuracy and speed—but only if calibration and quality control are handled correctly. By following best practices, lab professionals can:

• Ensure reliable test results

• Avoid downtime due to poor calibration

• Stay compliant with industry standards

• Protect patient outcomes

Calibrate often, monitor quality daily, and keep records clean. That’s how to get the best from your Alinity CI.